Mining Microarray

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ORIGIN OF MICROARRAY


-Many experiments on molecular biology since 1970

-Development of DNA sequencing

-Polymerase Chain Reaction (PCR)

WHAT IS MICROARRAY ?


-Ordered set of DNA molecule of known sequence

-May consists of few hundreds to hundred of thousands

-Individual feature in the array at precisely definite location of the substrate

-Identity of the DNA molecule never changes


IMPORTANCE OF MICROARRAY


-They are small in size

-They can contain a large number of genes

-Revolutionary change in gene expression

-Identification of genes causing deadly diseases


DNA MICROARRAY


-Array means to place in an orderly or fixed way

-These are small, solid supports onto which the sequences from thousands of different genes are attached at fixed locations

-cDNA derived from mRNA is mostly used