09-04-2011, 01:05 PM
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Case Study
Imagine…
You’re an undergrad at NU…
As you approach Finals Week you acquire the following symptoms:
Headaches
Nausea
Searle? à Mono
Evanston Northwestern Healthcare à MRI
Diagnosis and Treatment
Diagnosis: Benign Brain Tumor
Treatment:?
Chemo/Immuno therapy
Invasive brain surgery
Non-invasive radiotherapy
Non-invasive stereotactic radiosurgery
Diagnosis: Benign Brain Tumor
Treatment:?
Chemo/Immuno therapy à Blood Brain Barrier
Invasive brain surgery
Non-invasive radiotherapy
Non-invasive stereotactic radiosurgery
Diagnosis: Benign Brain Tumor
Treatment:?
Chemo/Immuno therapy à Blood Brain Barrier
Invasive brain surgery à High Risk
Non-invasive radiotherapy
Non-invasive stereotactic radiosurgery
Diagnosis: Benign Brain Tumor
Treatment:?
Chemo/Immuno therapy à Blood Brain Barrier
Invasive brain surgery à High Risk
Non-invasive radiotherapy à Too Non-Specific
Non-invasive stereotactic radiosurgery
Diagnosis: Benign Brain Tumor
Treatment:?
Chemo/Immuno therapy à Blood Brain Barrier
Invasive brain surgery à High Risk
Non-invasive radiotherapy à Too Non-Specific
Non-invasive stereotactic radiosurgery
What is Stereotactic Radiosurgery?
Method to non-invasively & specifically treat benign/malignant tumors and tissue abnormalities
Uses methods of stereotactic 3-D localization of surgical site
Uses radiosurgical techniques to perform the “surgery”
3-D Stereotactic Localization
Goal: To target the tissue of interest with as much accuracy as possible
Use imaging and 3-D mapping techniques to target tissue of interest
4 general medical imaging modalities used:
X-Ray
PET
MRI
Digital Subtracted Angiography
Use the patient as a reference for the localization
2 general methods:
Frame stereotactic localization (old school)
Frameless stereotactic localization (new school)
The Imaging Modalities
Tomographic Techniques:
PET (CT) and MRI
Good for tumor pathologies
Use multiple layers to get 3-D image
X-ray-based Techniques:
X-ray and Digital Subtracted Angiography
Good for vascular imaging (for treatment of vascular malformations)
Use pins and depth perception methods to get 3-D localization