18-10-2010, 02:13 PM
[attachment=6452]
Gene Prediction: Similarity-Based Approaches
Outline
The idea of similarity-based approach to gene prediction
Exon Chaining Problem
Spliced Alignment Problem
Gene prediction tools
Similarity-Based Approach to Gene Prediction
Genes in different organisms are similar
The similarity-based approach uses known genes in one genome to predict (unknown) genes in another genome
Problem: Given a known gene and an unannotated genome sequence, find a set of substrings of the genomic sequence whose concatenation best fits the gene
Gene Prediction: Similarity-Based Approaches
Outline
The idea of similarity-based approach to gene prediction
Exon Chaining Problem
Spliced Alignment Problem
Gene prediction tools
Similarity-Based Approach to Gene Prediction
Genes in different organisms are similar
The similarity-based approach uses known genes in one genome to predict (unknown) genes in another genome
Problem: Given a known gene and an unannotated genome sequence, find a set of substrings of the genomic sequence whose concatenation best fits the gene
