I want to write project topic in pharmaceutical technology

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nanotechnology drug delivery system on the review of pharmaceutical technology order to delivery in united state pharmacopeia

Master of Pharmacy is the post graduate degree programme awarded by numerous universities in India. It is a two year programme which includes the study of various pharmaceutical related subjects. Candidates who have completed the undergraduate degree in pharmacy i.e. B.Pharm from any reputed university can apply for this course. There are many career opportunities for the M.Pharm graduates. They can find jobs in various pharmaceutical companies, hospital pharmacies, reputed universities, etc. Enhancement of dissolution of Irbesartan using different techniques – The aim of this project is to improve the solubility and the dissolution speed of the Irbesartan with a solid dispersion technique. The process employs various super disintegrants like CCS, SSG, MCC and CP. The solid dispersions can be made using physical mixing and solvent desertion.

List of project ideas
Projects at the Department of Pharmaceutics and Analytical
Chemistry
A1. Process analytical technology, PAT (JTR)
Process analytical technology (PAT) is a new way to look into pharmaceutical production. The
main aim is to achieve relevant information during processing and by this means increase the level
of safety.
Current projects in this area cover the unit operations related to solid dosage forms, specifically the
implementation of non-invasive spectroscopic methods for process monitoring and control purposes.
Students have a possibility for industrial and academic projects in both Denmark and outside of
Denmark (UK, USA, Sweden, and Finland).
Max. number of students: 2
For further information, please contact Jukka Rantanen at The Department of
Pharmaceutics and Analytical Chemistry: jtr[at]farma.ku.dk
A2. Dry powder inhalation, DPI, at AstraZeneca, Lund
Pulmonary drug delivery technologies are one of the key formulation possibilities for challenging
new molecules. However, we should be able to design particles with controlled properties. This
project is aiming to develop new insights into characterization of critical particulate properties in
relation to dry powder inhalation products. Main focus is on relating segregation tendency to the
surface characteristics of powder particles. Exsperimental work will be performed at AstraZeneca
(Lund).
For further information, please contact Jukka Rantanen at The Department of
Pharmaceutics and Analytical Chemistry: jtr[at]farma.ku.dk
A3. Drug – biomacromolcule interactions.
Determination of equilibrium constants and association- and dissociation rate constants. The
interaction of a drug substance with a receptor or a protein is usually characterized by a binding or
equilibrium constant (K). The equilibrium constant is given by the ratio between the association and
the dissociation rate constants (ka/kd). The magnitudes of the rate constants may be of importance
to the fate of drug substances in the body. For instance, the dissociation rate constant of a drug –
albumin complex may be a determining factor for liver uptake and metabolism of a strongly bound
drug. The aim of the project is to develop and validate capillary electrophoresis (CE) and surface
plasmon resonance (SPR) methods for the determination of equilibrium and rate constants.
Max students: 1-2
For further information, please contact Jesper Østergaard or Henrik Jensen at The
Department of Pharmaceutics and Analytical Chemistry: joe[at]farma.ku.dk or
hj[at]farma.ku.dk
A4. Pharmaceutical profiling of drug substances using capillary electrophoresis and
electrochemical techniques
The chemical structure of a drug substance determines its degree of interaction with pharmaceutical
excipients, e.g. cyclodextrins, surfactants and polymers, propensity for ion pair formation, self
association, and distribution in two-phase systems. The objective of the project is to develop new
micro techniques based on electrochemistry and capillary electrophoresis for the investigation of
distribution and complexation phenomena. The methodologies are characterized by being fast and
requiring small amounts of sample only. Hence, they may be used in drug discovery/ early drug
development potentially offering a more thorough physical chemical characterization at an earlier
time point and a better starting point for subsequent drug development.
Max students: 1-2
For further information, please contact Jesper Østergaard or Henrik Jensen at The
Department of Pharmaceutics and Analytical Chemistry: joe[at]farma.ku.dk or
hj[at]farma.ku.dk
A5. Adsorption of protein drug compounds to oil-water interfaces
An increasing number of drug compounds under development are based on proteins and other
biological macromolecules. This type of drug compounds requires different strategies with respect
to development, production and analysis as compared to more traditional drug compounds based on
smaller molecules. For example, proteins may change their structure irreversible upon adsorption to
interfaces (such as those between water and oil) and thereby loose the pharmacological effect. The
purpose of this project is to investigate the adsorption of proteins and other macromolecules to oilwater
interfaces using a surface sensitive electrochemical method. Adsorption to the oil-water
interface can be compared to adsorption onto modified gold surfaces studied by SPR (Surface
Plasmon Resonance) techniques. The adsorption measurements will be supported by studies on
protein interactions in aqueous solution in order to investigate how potential excipients may
influence the adsorption.
Max students: 1-2
For further information, please contact Jesper Østergaard or Henrik Jensen at The
Department of Pharmaceutics and Analytical Chemistry: joe[at]farma.ku.dk or
hj[at]farma.ku.dk
A6. Development of Drug Sensors for Monitoring Drug Compounds
Throughout the development phase as well as on later stages there is a demand for analytical
methods facilitating the measurement of drug compounds in different matrices such as blood,
plasma, skin or urine. Traditional approaches typically involve separate sampling, sample
preparation separation and detection steps. It will be advantageous if the analysis can be performed
on-site and not be dependant on advanced laboratory facilities. The objective of the present project
is thus to design sensitive and specific drug sensors. By means of such sensors it will ultimately be
possible to monitor individual drugs, their metabolism and disposition and thereby secure proper
dosing of the drug compound. In this way unwanted side effects can be avoided. The sensors will
mainly be based on electrochemical principles, but techniques based on SPR (Surface Plasmon
Resonance) will be included where relevant.
Max students: 1-2
For further information, please contact Henrik Jensen at The Department of Pharmaceutics
and Analytical Chemistry: hj[at]farma.ku.dk
A7. Liposome – drug interactions
Liposomes consist of a lipid double layer. The structural characteristics resemble to a large degree
those of biological membranes and, consequently, liposomes constitute an attractive model of such
membranes. Furthermore, drug delivery systems based on liposome technology has been
investigated and utilized for a number of years. The objective of the project is to develop capillary
electrophoresis (CE) and surface plasmon resonance (SPR) based micro-analytical methods for
investigation of drug – liposome interactions. The methods will be used for characterization of drug
– liposome distribution coefficients, membrane adsorption, and membrane permeability studies as
well as for the characterization of liposome drug delivery vehicles, e.g. stability, drug incorporation
efficiency and membrane leakage.