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ABSTRACT
The trend among pharmaceutical companies to develop selective drugs of high potency
has pushed the industry to consider the potential of each hazardous ingredient to become
airborne.Dustiness issues are not unique to the pharmaceutical industry, but are relevant
to any industry where powdered materials are mixed, transferred and handled. Interest in
dustiness is also driven by concerns for worker health, the potential for plant explosions
and the prevention of product loss. Unlike other industries, the pharmaceutical industry is
limited by the milligram quantity of powdered material available for testing during
product development. These needs have led to the development of a bench-top dustiness
tester that requires only 10 mg of powder and fully contains the generated aerosol. The
powder is dispersed within a 5.7 liter glass chamber that contains a respirable mass
sampler and a closed-face sampler to quantify the respirable and total dust that are
generated with a given energy input. The tester distinguished differences in dustiness
levels of five different powders. Finer powders were dustier, and the respirable dust
percentage was always less than that for total dust. Four testers have been built and
evaluated using pharmaceutical grade lactose. Dustiness measurements determined using
all four testers were comparable. The pharmaceutical industry uses surrogates such as
lactose to represent active compounds in tests that estimate the dust concentration likely
to occur in a new manufacturing operation. Differences between the dustiness of the
active compound and its surrogate challenge the relevance of the surrogate tests to
represent true exposures in the workplace. The tester can determine the dustiness of both
the active compound and its surrogate, and the resultant ratio can help to interpret dust
concentrations from surrogate tests. Further, dustiness information may allow the
pharmaceutical researcher to select powder formulations that present low airborne
concentrations in the workplace
EXECUTIVE SUMMARY
Dust extraction system is used for many industries like as:
Asphalt industry
The dust-bearing exhaust gases are fed into the dust collector at a temperature of 100 –
170°. The separation of coarser particles is carried out in a pre-separator (separation >
90mμ) and a skimmer (separation > 63mμ). The exhaust gases enter the filter’s crude gas
chamber from above via the crude gas hood and then flow through the filter bags into the
clean gas chamber. The achieved residual dust content lies well below the prescribed
limiting value. The separated dust (sand and fine fillers) is fed back into the mixing
process by discharge elements and screw conveyors. A main radial fan blows the purified
gases out into the atmosphere via a chimney stack.
Cement industry
Cement manufacturing, handling,storage and distribution involve processes that require dust
control.
Quarry and minerals industry
Dantherm has long experience in providing centralised dust extraction installarions and individual
units for mineral handling and processing, from aggregates to clay preparation for brick and
ceramics manufacture. Tough reverse jet and reverse air filter units, with generous pre-separation
sections and hard grade ducting can handle heavy abrasive dust loads efficiently and with
minimal maintenance requirements. Crushing, screeniing, conveying, storage and outloading may
be handled by a single centralised dust extraction plant if required.
Pharmaceutical industry
Pharmaceutical dust extractor machine is extremely useful in controlling the dust generated during the
compression of tablets. These equipments are used to remove excess powder from compressed tablets.
These Dust Extractor Machine is not only ensure a dust free end product for use but also health and
safety of people coming in contact with pharmaceutical processing machines. Extracting hazardous
dust at the point of origination and conveying them to the correctly designed filtration system is
necessary to protect both personnel as well as the plant. These Dust Extractor Machine successfully
capture dust with the air stream and convey it to the dust collector.