presented by:
Sanjay Vasoya

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Nanoparticles for Nanomedicine
Targeted Delivery to Tumors
Many Different Length Scales
Relative Size of Nanoparticles
Making Gold Nanoparticles
Fluorophores and Drugs Selectively Dissociate Inside Cells
Control of Surface Charge
Investigating Delivery Using Cylindroids
Nanoparticles in Cylindroids
How Does Particle Charge Affect Tissue Penetration?
Engineering Approach:
Targeted Intratumoral Therapy
• Quantify tumor microenvironments
• Develop vectors to target tumor quiescence
Bacterial Penetration into Cylindroids
Microenvironments in Cylindroids
Bacteria Accumulate in Mouse Tumors
Control of Cytotoxicity
1. Inject modified bacteria
2. Induce peptide with radiation
Tumor Growth and Mouse Survival