Molecular hinges
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Molecular hinges in protein folding

Water as a Molecular
Hinge

Protein structure and stability are governed largely by hydrophobic collapse and hydrophilic interactions with water.bridges are formed by the Single embedded water molecules between oxygen atoms of different amide groups via double hydrogen bond formation. biomolecular chains can be held by them in this way. Thus they assist in the formation of tertiary structures. Here, single water molecules bridged between two amide groups is studied. Here, a dilute solution of water dissolved in N,N-dimethylacetamide (DMA) is used as the test solution. The three-dimensional rotational behavior of the water molecules engaged in bonds is developed by this experiment.

for more details, visit this pdf:
http://www-old.amolf.nl/publications/the...chap06.pdf
http://ncbi.nlm.nih.gov/pubmed/12379110
http://pnascontent/99/10/6631.abstract?cited-by=yes&legid=pnas;99/10/6631
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