Please post human artificial chromosome because my own interests...
human artificial chromosome
A human artificial chromosome (HAC) is a microchromosome that a new population of human cells can function as chromosome. That is why instead of 46 chromosomes, cell 47 with 47th can be very small, roughly 6-10 megabases (MB) natural chromosomes instead of 50-250 MB in size, and introduced new genes by human researchers able to move. Ideally, researchers from different genes that disease functions including can integrate a variety of performance.
Such yeast artificial chromosomes and bacterial artificial chromosomes as the use of alternative methods of Transgenes, give rise to unexpected problems. Started by genetic material of these vectors not only leads to different expression level, but includes also the original genome. [1] in this regard, different HACs interrupted as they are completely different chromosomes. Existing genetic material it considers that there is no separation insarshanal mutants is born. Stability and accuracy such as viral vectors, YACs and bex makes better HACs in other ways. HACs compared to viral delivery vectors more DNA is possible with (promoters and copy number variation including) allow for.
ek maanav krtrim gunasootr (hach) ek michrochhromosomai ki maanav koshikaon kee aabaadee mein ek naya gunasootr ke roop mein kaary kar sakate hain. yahee kaaran hai ki 46 gunasootron ke bajaay, sel 47 ven bahut chhote hone ke saath 47 ho sakata hai, mote taur par 6-10 maigabasais (emabee) praakrtik gunasootron ke lie 50-250 emabee kee bajaay aakaar mein, aur maanav shodhakartaon dvaara shuroo kee naee jeen le jaane mein saksham . aadarsh roop mein, shodhakartaon ne alag alag jeen hai ki rog se raksha sahit kaaryon kee ek kism ke pradarshan ko ekeekrt kar sakata.
aise khameer krtrim gunasootron aur baikteeriyal krtrim gunasootron ke upayog ke roop mein banaane transgainais ke vaikalpik tareekon, apratyaashit samasyaon ko janm de. aanuvanshik in vaiktar dvaara shuroo kee saamagree na keval vibhinn abhivyakti ke star kee or jaata hai, lekin sammilit karata hai isake alaava, mool jeenom. [1] hachs is sambandh mein alag baadhit roop mein ve pooree tarah se alag kromosom hote hain. maujooda aanuvanshik saamagree se yah judaee maanata hai ki koee insarshanal myootent paida hota hai. yah sthirata aur sateekata is tarah ke vaayaral vaiktar, yachs aur beks roop mein any tareekon ke lie behatar hachs banaata hai. hachs adhik deeene ke prasav kee tulana mein vaayaral vaiktar ke saath sambhav hai (pramotaron aur kopee sankhya bhinnata sahit) ke lie anumati dete hain.
Posts: 636
Threads: 0
Joined: Jun 2016
A human artificial chromosome (HAC) is a microchromosome that can act as a new chromosome in a population of human cells. That is, instead of 46 chromosomes, the cell could have 47 with the 47th being very small, roughly 6-10 megabases (Mb) in size instead of 50-250 Mb for natural chromosomes, and able to carry new genes introduced by human researchers. Ideally, researchers could integrate different genes that perform a variety of functions, including disease defense.
Alternative methods of creating transgenes, such as utilizing yeast artificial chromosomes and bacterial artificial chromosomes, lead to unpredictable problems. The genetic material introduced by these vectors not only leads to different expression levels, but the inserts also disrupt the original genome.[1] HACs differ in this regard, as they are entirely separate chromosomes. This separation from existing genetic material assumes that no insertional mutants would arise. This stability and accuracy makes HACs preferable to other methods such as viral vectors, YACs and BACs. HACs allow for delivery of more DNA (including promoters and copy-number variation) than is possible with viral vectors.
Posts: 14,118
Threads: 61
Joined: Oct 2014
Human artificial chromosome
A human artificial chromosome (HAC) is a microchromosome that can act as a new chromosome in a population of human cells. That is, instead of 46 chromosomes, the cell could have 47 with the 47th being very small, roughly 6-10 megabases (Mb) in size instead of 50-250 Mb for natural chromosomes, and able to carry new genes introduced by human researchers. Ideally, researchers could integrate different genes that perform a variety of functions, including disease defense.
Alternative methods of creating transgenes, such as utilizing yeast artificial chromosomes and bacterial artificial chromosomes, lead to unpredictable problems. The genetic material introduced by these vectors not only leads to different expression levels, but the inserts also disrupt the original genome. HACs differ in this regard, as they are entirely separate chromosomes. This separation from existing genetic material assumes that no insertional mutants would arise. This stability and accuracy makes HACs preferable to other methods such as viral vectors, YACs and BACs. HACs allow for delivery of more DNA (including promoters and copy-number variation) than is possible with viral vectors.
Yeast artificial chromosomes and bacterial artificial chromosomes were created before human artificial chromosomes, which first appeared in 1997. HACs are useful in expression studies as gene transfer vectors, as a tool for elucidating human chromosome function, and as a method for actively annotating the human genome.
Posts: 391
Threads: 0
Joined: Jul 2016
human artificial chromosome
A human artificial chromosome (HAC) is a microchromosome that a new population of human cells can function as chromosome. That is why instead of 46 chromosomes, cell 47 with 47th can be very small, roughly 6-10 megabases (MB) natural chromosomes instead of 50-250 MB in size, and introduced new genes by human researchers able to move. Ideally, researchers from different genes that disease functions including can integrate a variety of performance.
Such yeast artificial chromosomes and bacterial artificial chromosomes as the use of alternative methods of Transgenes, give rise to unexpected problems. Started by genetic material of these vectors not only leads to different expression level, but includes also the original genome. [1] in this regard, different HACs interrupted as they are completely different chromosomes. Existing genetic material it considers that there is no separation insarshanal mutants is born. Stability and accuracy such as viral vectors, YACs and bex makes better HACs in other ways. HACs compared to viral delivery vectors more DNA is possible with (promoters and copy number variation including) allow for.
ek maanav krtrim gunasootr (hach) ek michrochhromosomai ki maanav koshikaon kee aabaadee mein ek naya gunasootr ke roop mein kaary kar sakate hain. yahee kaaran hai ki 46 gunasootron ke bajaay, sel 47 ven bahut chhote hone ke saath 47 ho sakata hai, mote taur par 6-10 maigabasais (emabee) praakrtik gunasootron ke lie 50-250 emabee kee bajaay aakaar mein, aur maanav shodhakartaon dvaara shuroo kee naee jeen le jaane mein saksham . aadarsh roop mein, shodhakartaon ne alag alag jeen hai ki rog se raksha sahit kaaryon kee ek kism ke pradarshan ko ekeekrt kar sakata.
aise khameer krtrim gunasootron aur baikteeriyal krtrim gunasootron ke upayog ke roop mein banaane transgainais ke vaikalpik tareekon, apratyaashit samasyaon ko janm de. aanuvanshik in vaiktar dvaara shuroo kee saamagree na keval vibhinn abhivyakti ke star kee or jaata hai, lekin sammilit karata hai isake alaava, mool jeenom. [1] hachs is sambandh mein alag baadhit roop mein ve pooree tarah se alag kromosom hote hain. maujooda aanuvanshik saamagree se yah judaee maanata hai ki koee insarshanal myootent paida hota hai. yah sthirata aur sateekata is tarah ke vaayaral vaiktar, yachs aur beks roop mein any tareekon ke lie behatar hachs banaata hai. hachs adhik deeene ke prasav kee tulana mein vaayaral vaiktar ke saath sambhav hai (pramotaron aur kopee sankhya bhinnata sahit) ke lie anumati dete hain.
