07-11-2017, 11:52 AM
MODELLER is used for the homology or comparative modeling of three-dimensional protein structures (1,2). The user provides an alignment of a sequence that will be modeled with known related structures and MODELLER automatically calculates a model that contains all non-hydrogen atoms. MODELLER implements comparative modeling of protein structure for satisfaction of spatial constraints (3,4) and can perform many additional tasks, including de novo modeling of loops in protein structures, optimization of several protein structure models with respect to a defined objective function of flexible manner, multiple alignment of protein sequences and / or structures, grouping, search of sequence databases, comparison of protein structures, etc. MODELLER is available for download for most Unix / Linux, Windows and Mac systems.