Hello,
My name is Antonio and I found that in the article" Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering" your program was used to design the scaffold. I'm current looking for a way to make a TALEN less repetitive in the scaffold and I was wondering if the program modeller 9v4 could help me to design a scaffold in which the non-variable residues could vary just enough to avoid a highly repeated DNA sequence. I'm currently an student of microbiology in the university of BYU, Utah, USA. Thank you.
Sincerely
Antonio Solis
a.solisleal[at]gmail.com
Posts: 14,118
Threads: 61
Joined: Oct 2014
MODELLER is used for the homology or comparative modeling of three-dimensional protein structures (1,2). The user provides an alignment of a sequence that will be modeled with known related structures and MODELLER automatically calculates a model that contains all non-hydrogen atoms. MODELLER implements comparative modeling of protein structure for satisfaction of spatial constraints (3,4) and can perform many additional tasks, including de novo modeling of loops in protein structures, optimization of several protein structure models with respect to a defined objective function of flexible manner, multiple alignment of protein sequences and / or structures, grouping, search of sequence databases, comparison of protein structures, etc. MODELLER is available for download for most Unix / Linux, Windows and Mac systems.
