BIO - CHEMIST - THE PHARMACEUTICAL CORPORATION - IM - KERALA LTD.pdf (Size: 1.32 MB / Downloads: 1)

1. Which of the following intermediates of TCA cycle cannot be utilized for gluconeogenesis ?
(A)Succinate
(B)Malate
(C ) a - Keto glutarate
(D) Acetyle CoA

2. Which statement best explains the function of the nuclear pore complex ?
(A)It organizes DNA into at least five different levels of packing
(B)It determines which genes each cell will express
(C )It defines the regions of chromosomes that are replicated first during cell division
(D)It determines which proteins pass into and out of the nucleus

3.The function of cAMP in a cell is :
(A) To activate a G protein
(B)To remove phosphate groups from ATP
(C ) To activate kinases
(D)To bind to the first messenger

4.The Na f -K+ pump is : 
(A) Peripheral protein
(B)An integral protein
(C ) AG- protein
(D)A glycolipid

5.If a protein contains a primary binding site and an allosteric site, what else can you predict about this protein ?
(A)Occupancy of the allosteric site alters the binding affinity of the primary site
(B)The primary binding site has a higher concentration of hydrophobic amino acids than the allosteric site
(C )The protein has quaternary structure
(D) The primary binding site and allosteric site form a domain

6.Which of the following substance may not be useful in stabilizing enzyme solution ?
(A)Proteins
(B) Bile salts
(C ) Kucleic acids 
(D) Amino acids

7.Which of the following best defines immunotoxins ?
(A)Toxic substances released by macrophages
(B)Cytokines
(C )Toxins coupled to antigen-specific immunoglobulins
(D)Toxins released by cytotoxic T cells

8.FSI1 secretion begins to rise and new follicles begin to grow during :
(A)the premenstrual phase
(B) The menstrual phase
(C ) The preovulary phase
(D) The luteal phase

9.Construction of a restriction map of DNA requires all of the following except:
(A)Complete hydrolysis of DNA
(B)Partial hydrolysis of DNA
(C )Cyclic heating and cooling of the reaction mixture
(D)Klectrophorutic separation of fragments on a gel

10.Onetheory of senescence is that it results from a lifetime of damageby :
(A)Teratogens 
(B) Aneuploidy 
(C ) Free radicals
(D)Cytomegalovirus

11.Hie function of endonucleases during eukaryotic transcription termination is :
(A)To expose the TATA sequences in the primary transcript
(B)To expose the polyadenylation site on the primary transcript
(C )To form a hairpin loop structure in the primary transcript
(D)To cut the primary transcript RNA away from the RNA polymerase

12.All the following are constituents of ganglioside molecules except:
(A)Glycerol
(B)Sialic acid
(C )Sphigosine
(D)Long chain fatty acid

13.PS-I gets de-energised electrons from :
(A)Water
(B)Plastoquinonc 
(C ) Plastocyanin
(D)Cytochrome f

14.One of them is a scientist involved in studies on vitamin D action :
(A)Antony Norman
(B)Antony Means
(C )Antony Quinn
(D)Mark Antony

15.Which of the following statements explains the use of fluorochromes in immunophenotyping by clinical flow cytometry ?
(A)Fluorochromes bind non-specifically to leukocytes
(B)All fluorochromes emit light at the same wavelength
(C ) Several fluorochromes can be excited by light of a single wavelength
(D)The wavelength of the emitted light is the same as that of the incident light

16.What do flippases and floppases do ?
(A)Synthesize phospholipids on both faces of a membrane
(B)Move phospholipids from one face of a membrane to the other
(C )Move proteins from one face of a membrane to another
(D)Change the shape of phospholipids from one stable conformation to another

17.Digestive enzymes are released by pancreas and bile is released by the liver in response to the hormone :
(A)Gastrin
(B) Zymogen
(C ) Cholecystokinin 
(D) Insulin

18.Membrane carriers icsembles enzymes except for the fact that carriers :
(A)Are not protein
(B)Do not have binding sites
(C )Do not chemically change their ligands
(D)Change confirmation when they bind a ligand

19.Gibberellins stimulate:
(A)Oil division
(B) Growth of lateral roots
(C )Curvature of coleoptiles
(D)Elongation of intemode

20.Galactosemia is due to deficiency of ;
(A)Galactose-1-phosphate UDP transferase
(B)Galaclokinase
(C )Galactose-4-epimerase
(D)All the above

21.Citrate is converted to isocitrate by aconitase which contains :
(A)Ca^
(B)Fe++
(C )Zn++
(D)Mg++

22.When the fluid outside a cell has a greater concentration of a given molecule than the fluid inside the cell, the external fluid is :
(A)Isotonic
(B)Hypertonic
(C )Hypotonic
(D)Ultratonic

23.eRFl is release factor in eukaryotes that require :
(A)ATP for its binding to ribosome
(B)GTP for its binding to ribosome
(C )ATP and G TP for its binding to ribosome
(D)Mn2+ for its binding to ribosome

24.A molecule of CO-> is captured by biotin when it acts as coenzyme for carboxylation reaction. The carboxyl group is covalently attached to :
(A)A nitrogen (N-j) of the biotin molecule
(B)Sulphur of thiophene ring
(C )cv-Amino group of lysine
(D)u-Amino group of protein

25.Which of the following cytokines plays a role in terminating inflammatory responses ?
(A)II.-2
(B) IL-1 
(C ) TGF-P
(D) IFN-n

26.During the formation of urine in the kidney, most of the water is reabsorbed into the blood in the :
27.The following points about microfilaments are true except :
(A)They form cytoskeleton with microtubules
(B)They provide support and shape
(C )They form intracellular conducting channels
(D)They are involved in muscle cell contraction

28.Production of more than one phenotypic trait by a single gene is called :
(A)Pleiotrophy
(B)Genetic determinism
(C )Codominance
(D)Genetic recombination

29.Hydrolases are involved in hydrolysis of:
(A)Esters
(B)Glycosidic bonds
(C )Peptide bond
(D)All the above

30.What are cadherins ?
(A)Proteins that permit adjacent cells to form adherens junctions
(B)Proteins that link the basal membrane of epithelial cells to laminins
(C )Proteins that bind intergrins to intermediate filaments in skin cells
(D)Proteins that allow white blood cells to cone to a rolling stop in blood vessels

31.The glial cells that destroy micro-organism in the CNS are :
(A)Microglia
(B)Satellite cells
(C )Oligodendrocytes
(D)Astrocytes

32.Which of the following does not contribute to the resolution attainable by a microscope ?
(A)The refractive index of the material between the specimen and the lens
(B)The numerical aperture of the lens
(C )The magnitude of the objective lens
(D)The wavelength ofthe light

33.Which of the following does not occur during PCR ?
(A)Production of many pieces of single-slranded DNA
(B)The amount of DNA doubles with each round of replication
(C )Repeating cycles of heating and cooling DNA
(D)The strands of the original DNA sample are unwound

(A) Ascending loop of henle 
(B)Descending loop of henle 
(C ) Distal convoluted tubule
(D)Proximal convoluted tubule

34.Tendons are compost of___________ _ connective tissue.
(A)Areolar
(B) Yellow elastic 
(C ) Dense regular 
(D) Skeletal

35.Which event does not take place during anaphase A and/or anaphase B ?
(A)Formation of kinetochore microtubules
(B)Elongation of polar microtubules
(C )Shortening of astral microtubules
(D)Movement of kinesin towards the plus end of polar microtubule

36.A light chain gene is constructed from the following segments :
(A)Variable and constant segments
(B)Variable, joining and constant segments
(C )Variable, diversity and constant segments
(D)Variable, joining, diversity and constant segments

37.In the purine nucleus, carbon 6 is contributed by :
(A)Glycine
(B)C02
(C ) Aspartate
(D) Glutamine

38.Some neurotransmitiers can have either excitatory or inhibitory effects depending on the type of:
(A)Receptors on the postsynaptic neuron
(B)Synaptic vesicles in the axon
(C )Neuromodulator involved
(D)Postsynaptic potentials on the synaptic knob

39.A purely competitive inhibitor of an enzyme has which of the following kinetics effects ?
(A)Increases Km without affecting Vmax
(B)Decreases Vmax without affecting Km
(C )Increases Vmax without affecting Km
(D)Decreases Km without affecting Vmax

40.Which of the following is not a step taken to produce recombinant DNA using human DNA ?
(A)Isolate and purify DNA from tissues and from plasmids.
(B)Use retroviruses to circularize DNA
(C )Cut both human and plasmid DNA with the same restriction enzymes
(D)Seal human DNA fragments into plasmids with DNA ligase

41.Oxamate is a competitive inhibitor of which of the following enzymes ?
(A)Hexokinase
(B) Phosphofructokinase
(C )Lactate dehydrogenase
(D) Pyruvate dehydrogenase

42.A high ratio of insulin to glucagon can :
(A)Promote glycogenolysis
(B)Found in Type 1 Diabetes Mellitus
(C )Occurs during fasting state
(D)Promotes synthesis of Glycogen

43.The ATP/ AMP ratio has a major effect upon the rate of ATP production by glycolysis. ATP and AMP bind to allosteric sites on :
(A)Ilexokinase
(B)Glucokinase
(C )Phosphofructokinase-l
(D)Phosphofructokinase-2

44.The function of an adjuvant in a vaccine is :
(A)Distribution
(B)Absorption
(C )Antigenicity
(D)Metabolism

45.Which of the following statements about dietary fiber is/are correct ?
(A)Insoluble fiber increases stool bulk and decreases transit time
(B)Water-soluble fiber helps to lower serum cholesterol in most people
(C )Mucilaginous fiber slows the rate of digestion and absorption of carbohydrate
(D)All of the above

46.Creatine kinase is an :
(A)Transferase
(B)Lyase
(C )Hydrolase
(D)Isomerase

47.Cholesterol inhibits estrogen action through its influence on :
(A)naER
(B)ERa
(C )nER II
(D)E-RAF

48.One out of the following enzymes can utilize both NAD+ and NADP+ as a coenzyme :
(A)Aldehyde dehydrogenase
(B)Alcohol dehydrogenase
(C )Glutamate dehydrogenase
(D)Glycerol-3-P dehydrogenase

49.Excretion of conjugated bilirubin from liver cells into biliary canaliculi is defective in:
(A)Gilbert's disease
(B)Crigler-Najjar syndrome
(C )Lucey-Driscoll syndrome
(D)Rotor's syndrome

50.Which signalling sequence uses both hydrocarbon and ions as second messengers ?
(A)PKC activation of RNA polymerase
(B)Ras activation of MSK.1
(C )Cyclin D/CDK4 activation of F.2F
(D)RTK activation of MAP kinase

51.The genetic code that directs protein synthesis in human is found in :
(A)All multicellular organisms, but not in unicellular ones
(B)No other kind of organism
(C )All animals, but not in plants
(D)Virtually all organism

What would be the consequence of defectiveADH receptors ?
(A) Diabetes mellitus
(B)Dehydration
(C ) Seasonal affective disorders
(D)None of the above

Which of the following is true ?
(A) IgM fixes complement
(B)IgC does not cross placenta
(C ) IgA binds mast cells
(D)IgK binds phagocytes

54.Why can smooth muscle cells remain contracted for longer than striated muscle cells ?
(A)They lack Z disc
(B)They store more calcium ions than striated muscle cells
(C )They are not multinucleated cells
(D)Their contraction relies on phosphorylation of myosin instead of iron fluxes

55.The inner mitochondrial membrane is rich in which of the following phospholipids ?
(A)Cardiolipin
(B)lecithin
(C )Cephaiin
(D)None of the above

56.The reason for the absence of testosterone in circulation in mammalian females is :
(A)Testosterone is not produced by the ovary
(B)Testosterone is fully converted to estradiol
(C )Testosterone produced is immediately entabolised
(D)The entire testosterone produced get excreted

57.The carbon atom of urea is derived from :
(A)Glycine
(B)Methionine
(C )Methylene tetrahydrofolatc
(D)Bicarbonate

58.In an individual at rest, who has fasted for 12 hours, which of the following occurs ?
(A)Gluconeogenesis is the major process by which blood glucose is maintained
(B)Glycogen synthase is activated in liver
(C )Adenylate cyclase is inactivated in liver
(D)Phosphorylase, pyruvate kinase and glycogen synthase are phosphorylated in liver

59.All are plant derived alkaloids except:
(A)Nicotine
(B)Menthol
(C )Codeine
(D)Quinine

60.Estrogen Receptor Activation Factor (E-RAF) is a :
(A)Estrogen binding protein
(B)Anticslrogen binding protein
(C )DNA binding protein
(D)A lipoprotein

61.One of the below is not modifiable risk factor for atherosclerosis :
(A)Smoking and Obesity
(B)Family History
(C )Hypertension and lipid disorders 
(D)Diabetes Mellitus

62.C4 plants show very high rate of photosynthesis as compare to C3 plants, because of:
(A)Dicarboxylation
(B)Bundle sheath cells
(C )Absence of photorespiration
(D)All the above

63.All of the following are oncogenic except:
(A)Papilloma virus
(B)EB virus
(C )Herpes simplex virus
(D)Varicella zoster virus

64.The glycosaminoglvcan which does not contain uronic acid is :
(A)Dermatan sulphate
(B)Chondroitin sulphate
(C )Keratan sulphate
(D)Heparan sulphate

65.Organ of adhesion of bacteria is :
(A)Capsule
(B)Fimbriae
(C )Slime
(D)Flagella

66.Epinephrine increases the concentration of free fatty acids in plasma by increasing :
(A)Extra mitochondrial fatty acid synthesis
(B)Mitochondrial fatty acid chain elongation
(C )Microsomal fatty acid chain elongation
(D)Lipolysis in adipose tissue

67.Which of the following factors will affect themeasurement of pH using a glass electrode ?
(A) Temperature
(B)Valency of ions present
(C ) Presence of salt
(D)Presence of Protein

68.All are natural auxins except :
(A) Indole acetic acid
(B)Napthalcne acetic add
(C ) Phenoxy acetic acid
(D)Indole-3-acetic add

69.Eukaryotes Jitter Irom prokaryotes in mechanism of DNA replication due to :
(A)Discontinuous rather than semi discontinuous replication
(B)Different enzyme for synthesis of lagging and leading strand
(C )Use of DMA primer rather than RNA primer
(D)Unidirectional rattier than bidirectional replication

70.The substance most likely to cause a rapid drop in blood pressure is :
(A) Epinephrine 
(B) Serotonin
(C ) Histamine 
(D) Angiotensin II

71.The translocation of Ca2+ across a membrane involve all of the following except:
(A)Phosphorylation of transporter
(B)Maintaining |Ca21 J very much higher in the cell than in extracellular fluid
(C )Regulation by the binding of a Ca2 1 Calmodulin complex to the transporter in eukaryotes
(D)Active transport by Ca2+ - transporting ATPase

72.All of the following represent control of a metabolic process by substrate availability except :
(A)Rate of ketogenesis
(B)Increased urea synthesis after a high protein meal
(C )Hypoglycemia of advanced starvation
(D)Response of glycolysis to fructose 2, 6-biphosphate

73.F factor integrates with bacterial chromosome to form :
(A)HFr
(B)R I F + r
(C )F~
(D)RTF

74.The surface tension in intestinal lumeti between fat droplets and aqueous medium is decreased by ;
(A)Bile Salts
(B)Bileacids
(C )Cone.H2S04
(D)Aceticacid

75.The immunoglobulin with the longest serum half-life is :
(A)IgD
(B)IgM
(C )IgG
(D)IgA

76.All of the following contribute to the large, negative, free-energy change upon hydrolysis of "high energy" compounds except :
(A)Electrostatic repulsion in the reactant
(B)Low activation energy of forward reaction
(C )Stabilization of products by extra resonance forms
(D)Stabilization of products by ionization


77.In rapidly dividing cancer cells the need for large amount of ribose is fulfilled by:
(A)Highly active Glucose-6-F dehydrogenase
(B)Reversal of non-oxidative phase using glycolytic intermediates
(C )Highly active Transaldolase
(D)Highly active 6-P-Gluconate dehydrogenase

78.Choose the incorrect statement about Amino Acid Glycine :
(A)One carbon donor
(B)Required for the synthesis of haem
(C )Forms oxalates upon catabolism
(D)Both glucogenic as well as ketogenic

79.Which of the membrane molecules are involved in antigen recognition and T cell activation ?
(A)CD3
(B)CD4 and CD8
(C )CD2 (LFA1, CD28)
(D)All of the above

80.The media for cultivation of anaerobic organism is :
(A)Salt agar
(B)Robertson's cooked meat broth
(C )Stuarts medium
(D)Chocolate agar

81."Ente Jecvitha Samarangal" is the autobiography of________.
(A)V.S. Aehuthanandan
(B)E.M.S. Nambodiripad
(C )Mannathu Padmanabhan
(D)K. Karunakaran

82.A foreigner to become the INC President twice :
(A)Henry Cotton
(B)George Yule
(C )Alfred Webb
(D)William Wedderbum

83.Black hole of Podanoor is related to :
(A)Mappila Lahala
(B)Malayalee Memorial
(C )Paliyam Sathyagraha
(D)Channar Lahala

84. How many ways by which a person can acquire Indian citizenship ?
(A) 3
(B) 4
(C ) 5
(D) 6

85.Article 280 deals with :,
(A)Information Commission
(B)Election Commission
(C )Finance Commission
(D)Planning Commission

86.The Headquarters of "Prathyaksha Raksha Daiva Sabha" (PRDS) located in which district ?
(A)Trivandrum
(B)Pathanamthitta
(C )Kolia m
(D)Idukki

87.Who wrote "AatmopadesaSathakam" ?
(A)Chattambi Swamikal
(B)Vagbhadananthan
(C )Sree Narayana Guru
(D)Ayyankali

88.Is1 Indian Blind Women to won Indian Civil Services examination - 2015 :
(A)Kiran Bedi
(B)Ben 5effin
(C ) Dr. Renu Raj
(D) Manu Gautami Sharma

89.Who won first Vayalar Award ?
(A)Lalithambika Antharjanam
(B)Ayyappa Panikar
(C )Sugatha Kumari
(D)O.N.V. Kurup

90.In which day is observed as the International Friendship day ?
(A)September 15
(B)July 30
(C )June 30
(D)January 30

91.Govt, of India recently launched a scheme called USTAAD to whom does it benefit ?
(A)Avurveda Doctors
(B)Sportsman
(C )Traditional Artisans
(D)Traditional Medical Practitioners

92.According to the World Happiness Report India was ranked_______________among 157
countries and the happiest countries were Switzerland, Iceland, Denmark, Norway and Canada.
(A)117
(B)108
(C )100
(D)106

93.Right to Education man dates all private unaided schools admit at least
of
their students in their entry-level class from socially disadvantaged and economically weaker group.
(A) 20
(B)15
(C ) 25
(D) 10

94.Who was the volunteer captain of Guruvayoor Sathyagraha ?
(A) T.K. Madhavan
(B) A.K. Gopalan
(C ) K. Kelappan
(D) K.P. Kesava Menon

95.The Prefix 'Mahakavi' awarded to kumaranasan from Madras University in the year : 
(A) 1922
(B)1912
(C )1924
(D) 1918


96.The most important property of nanomaterials is ,_____ 
(A)Force
(B)Friction
(C )Pressure
(D) Temperature

97.Which is the largest democracy of the world ?
(A)USA
(B)China
(C )India
(D) South Africa service.

98._________Government has launched India's First E - ration card
(A)Kerala
(B)Delhi
(C )Maharashtra
(D)Telangana

99.Present Chief Information Commissioner of India :
(A)Sushama Singh
(B)Deepak Shanthu
(C )Vijay Sharma
(D)K.V. Choudary

100.Who is known as the "Jhansi rani of Kerala" ?
(A)A.V. Kuttimalu Amma
(B)Akkamma Cheriyan
(C )Anna Chandi
(D)K.R. Gowri Amma